It is worth noting that along with the role of TGF-β, other signaling pathways such as PI3K/Akt, ERK/c-Jun amino-terminal kinases (JNK), Wnt/β-catenin, and NF-κB are also closely involved in the migration and invasiveness of HCC cancer cells and metastasis formation [29]. This evidence concerns the gene AKT1 and cancer.