TME regulates a plethora of cellular signaling pathways that control multiple stages of tumor progression and invasion, such as mitogen-activated protein kinase (MAPKs), PI3K/Akt, NF-κB, JAK/STAT, Wnt/β-catenin, TGF-β, and Notch [38]. This evidence concerns the gene NFKB1 and neoplasm.