Taken together, SC-1 carries three major rearrangements resulting in the gene fusions IGH::BCL2, IGH::MYC, and MBNL1::BCL6 which were characterized cytogenetically, genomically, and at the transcript level, thus, representing an exceptionally well characterized triple-hit B-cell lymphoma cell line. The gene discussed is MYC; the disease is B-cell non-Hodgkin lymphoma.