Intriguingly, our collective findings show that while neighboring homeobox gene HOXB9 and microRNA gene miR196a may promote HL, the analogous pair described here—HOXB5 and miR10a—playing comparable roles in non-HLs, raise the possibility that their close genomic proximities may reflect physiological cooperation in their respective developmental pathways. This evidence concerns the gene HOXB9 and Hodgkins lymphoma.