Collectively, our data show that chromosomal aberration t(14;17)(q32;q21) mediates activation of both homeobox gene HOXB5 and micro-RNA gene miR10a in triple-hit B-cell lymphoma cell line SC-1, and that aberrant overexpression of HOXB5 was also detected in subsets of BL, FL, and MM patients. The gene discussed is HOXB5; the disease is B-cell non-Hodgkin lymphoma.