Based on the brain distribution of the four ADPKD genes, it would be expected that patients with PKD1/PKD2 deletion (which are poorly expressed in the brain) might show some anxiety [75], whereas those with GANAB/DNAJB11 mutation (highly expressed in the brain) might have hyperactivity or memory loss [76,85]. The gene discussed is PKD2; the disease is autosomal dominant polycystic kidney disease.