Ando et al. [24] discovered that compared with the control group and apoptosis group, the expression of CXCL5 increased in necroptosis, its receptor CXCR2 was upregulated in PC and inhibition of CXCR2 suppressed necroptosis-induced migration and metastasis of PC cells. Here, CXCL5 is linked to pachyonychia congenita.