MLKL and neoplasm: A subsequent study pointed out that the effect of radiotherapy depends on the immune system rather than on direct induction of tumor cell death and that radiotherapy increases necroptosis through the ZBP1-MLKL pathway to release mitochondrial DNA of tumor cells, which is closely monitored by the intracellular CGAS-STING pathway then to initiate antitumor innate and adaptive immune responses [10].