Notably, the generation of ROS serves as a common upstream mechanism to activate the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasomes, which regulate caspase-1 activation, release Interleukin (IL)-1β/18, and trigger inflammatory responses to promote the pyroptotic process of atherosclerosis [9,10,11]. The gene discussed is NLRP3; the disease is atherosclerosis.