Axonal pathfinding disturbances are also increasingly thought to contribute to Alzheimer’s disease (AD) pathogenesis [8,9]; in particular, several axon guidance performers, such as netrin-1, ephA4 (a receptor of ephrins), and the semaphorin sema3A, are being unveiled as modulators (positive/negative) of AD pathogenesis, and prospective therapeutic targets. The gene discussed is EPHA4; the disease is Alzheimer disease.