ENO2 and neoplasm: The analysis of genomic epithelial serum tumor markers such as squamous cell carcinoma antigen (SCCA), carcinoembryonic antigen (CEA), or neuron-specific enolase (NSE) and cytokeratin 19 (CYFRA 21-1) [6], which have been reported to be elevated, may detect the disease only at advanced stages [7,8].