In a comprehensive review from 2023, Ghosh et al. [49] disscussed the various potential factors that play a role in the pathogenesis of NAFLD (for example, high-fat diet, adipose tissue dysfunction, intrahepatic de novo lipogenesis, hepatic fat accumulation, insulin resistance, hepatic inflammation and inflammasome activation, mitochondrial dysfunction, oxidative stress, etc.)and the possible ameliorative effects of melatonin. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.