Up to date, 17 X-chromosome genes have been associated with a syndromic form of hearing loss and, including COL4A5, which causes Alport syndrome, which is characterized by glomerulopathy, hearing loss, and lens abnormalities [5], and AIFM1, which is responsible for Charcot-Marie-Tooth syndrome, which is characterized by heterogeneous forms of motor and sensory neuropathies [6]. The gene discussed is AIFM1; the disease is hearing loss disorder.