GPC3 and hepatocellular carcinoma: Tumor endothelial marker 1 (TEM1), epithelial cell adhesion molecule (EpCAM) melanoma-associated gene-A1 (MAGE-A1), New York esophageal squamous cell carcinoma 1 (NY-ESO-1), AFP and glypican-3 (GPC-3) have been identified as specifically associated with HCC and leading to a T-cell response in the blood in about 50% of patients [161].