In addition, growing studies showed that a subset of unconventional gamma delta (γδ) T lymphocytes, harboring the Vγ9Vδ2 TCR (abbreviated as Vδ2pos) T cells, exert a potent antitumor activity in several cancers, and that the inhibitory NKG2A expression on these T cells may abolished the immune response, due to the HLA-E expression on the tumor cells in HCC [79,100] (Figure 2). The gene discussed is HLA-E; the disease is hepatocellular carcinoma.