Furthermore, the presence of inflammatory cytokines such as IL-10, IL15 and TGFβ, particularly abundant in the TME of HCC [88], has been shown to increase NKG2A expression on NK cells [88,89,90], and recently, a specific study of the gene signature once again suggested the CD94/NKG2-HLA-E system as the likely cause of the immune evasion of NK cells in HCC samples with higher levels of infiltrated NK cells characterized by the TGF-beta–Wnt interaction signature [91]. Here, KLRD1 is linked to hepatocellular carcinoma.