Several other peripherally restricted CB1R antagonists/inverse agonists were studied and showed anti-obesity effects and improvements in hormonal or metabolic abnormalities in rodent models of obesity, for example, URB 447, MJ08, SR141716, AM6545, ENP11, and NESS06SM [63,154,229], all of them requiring further investigation. The gene discussed is CNR1; the disease is obesity due to melanocortin 4 receptor deficiency.