It was confirmed that compound 4c inhibited NF-κB complex-related subunits such as p-IKKα/β and p-ΙκΒα, which were induced by TNFα in the cytoplasmic region of CML cells, when compared to 4c-untreated cells (Figure 3A,B). Here, CHUK is linked to chronic myelogenous leukemia, BCR-ABL1 positive.