IGF2 and esophageal squamous cell carcinoma: A study found miR-483-5p to be expressed in esophageal squamous cell carcinoma (ESCC), with low levels of IGF2 promoter methylation (associated with increased IGF2 expression) and proposed a permissive level for IGF2 promoter methylation towards the observed miR-483-5p tumor suppressing effects [125].