TNF and diabetes mellitus: Functional pathways identified were TNF signaling, AGE-RAGE signaling in diabetes, IL-17 signaling, NF-κB signaling, chemokine signaling, NOD-like receptor signaling, MAPK signaling, TLR signaling, T cell receptor signaling, complement and coagulation cascades, B cell receptor signaling, RIG-I-like receptor signaling, cytokine-cytokine receptor interaction, Th17 activation, and Th1 and Th2 activation (Table 3).