CYP3A4 and alcoholic liver diseases: The most prominent downregulation of metabolizing enzymes was associated with alcoholic liver disease (CYP1A2, CYP2C8, CYP2D6, CYP2E1, CYP3A4, UGT2B7) and primary biliary cholangitis (CYP1A1, CYP2B6, CYP2C8, CYP2E1, CYP3A4).