The most prominent downregulation of metabolizing enzymes was associated with alcoholic liver disease (CYP1A2, CYP2C8, CYP2D6, CYP2E1, CYP3A4, UGT2B7) and primary biliary cholangitis (CYP1A1, CYP2B6, CYP2C8, CYP2E1, CYP3A4). The gene discussed is CYP2E1; the disease is biliary liver cirrhosis.