The most prominent downregulation of metabolizing enzymes was associated with alcoholic liver disease (CYP1A2, CYP2C8, CYP2D6, CYP2E1, CYP3A4, UGT2B7) and primary biliary cholangitis (CYP1A1, CYP2B6, CYP2C8, CYP2E1, CYP3A4). Here, CYP2E1 is linked to alcoholic liver diseases.