MTOR and posterior cortical atrophy: The inclusion of CD44v6 in PCa cells has been linked to a surge in cell proliferation, the formation of spheres, and resistance to various forms of chemotherapy, such as docetaxel, paclitaxel, doxorubicin, methotrexate, and even radiotherapy due to its involvement in the EMT process as well as activation of the PI3K/Ak/mTOR and Wnt/β-catenin pathways [118].