The overexpression of HECT and Copper Zinc Superoxide Dismutase Domain containing protein 1 (HACE1) in glioma tissues competes with Keap1 to prevent Nrf2 from being degraded via ubiquitination at the post-translational modification level and promotes the upregulation of Nrf2 transcriptional expression via the internal ribosome entry site (IRES) through La/SSB [76]. This evidence concerns the gene NFE2L2 and central nervous system cancer.