HMOX1 and posterior cortical atrophy: Knocking down Nrf2 in PCa DU145 cells can decrease the expression of oxidative-stress-related genes, such as NAD(P)H:Quinone oxidoreductase 1 (NQQ1), superoxide dismutase 2 (SOD2), and heme oxygenase-1 (HO-1), making the cells more sensitive to cis-platinum and inducing DNA damage response [75].