ERBB2 and neoplasm: For example, it was possible to construct plasmids containing the variable region sequence of the trastuzumab (anti-HER2) mAb for the transformation of Bifidobacterium strains (a bacterium that could be safely and selectively accumulated under hypoxic conditions) for the in situ production of Trastuzumab scFv at the tumor site and the inhibition of HER2-mediated signaling pathways [155] (Figure 6A).