WFS1 and Hodgkins lymphoma: DFNA1 is due to mutations in the DIAPH1 gene on chromosome 5q31 and causes progressive low-frequency HL, resulting in a profound degree by the fourth decade of life [18,19]; conversely, DFNA6/14/38 is due to mutations in the WFS1 gene on chromosome 4p16 and does not progress to profound HL [33].