One study showed that exposure to 5-FU increased microRNA secretion in colon cancer cells, resulting in altered intracellular physiology and resistance to treatment [78], while another study also uncovered that microRNA transport through exosomes decreased the expression of CyclinD1 in glioblastoma cells, resulting in cellular quiescence and chemoresistance [79]. The gene discussed is CCND1; the disease is malignant colon neoplasm.