In their series of 75 cases from those published, they highlight the frequency of hematologic disorders (50% red cell aplasia, 55% leukopenia) and viral infections (about 40% of cases, mainly CMV), despite the heterogeneity of immunological findings (reduced B cells in 33/38, inverted CD4/CD8 ratio in 22/24, low CD4+ T cells in 9/20). This evidence concerns the gene CD4 and viral infectious disease.