Other confirmed genes in ALS are VAPB, EPHA4, UNC13A, NEK1, SOD1, HNRNPA1, ANXA11, UBQLN2, PFN1, and KIF5A, whereas GRN, MAPT, and CHMP2B mutations have been found solely in FTD [16]. The gene discussed is CHMP2B; the disease is amyotrophic lateral sclerosis.