These genes include SOD1 and UBQLN2 (in ALS), CHMP2B, MAPT, GRN and SQSTM1 (in FTD) and OPTN, C9ORF72 and TBK1 in both ALS and FTD (Figure 2, Table 1). The gene discussed is CHMP2B; the disease is amyotrophic lateral sclerosis.