In keeping with this, a previous proteomic study of insoluble material obtained from the brain of patients suggested that many proteins can potentially become recruited or trapped by TDP-43 aggregates: in one study laser capture microscopy coupled with mass-spectrometry detected altered proteins in hippocampal dentate granule cells excised from three post-mortem FTD cases. The gene discussed is TARDBP; the disease is frontotemporal dementia.