These genes include SOD1 and UBQLN2 (in ALS), CHMP2B, MAPT, GRN and SQSTM1 (in FTD) and OPTN, C9ORF72 and TBK1 in both ALS and FTD (Figure 2, Table 1). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.