COL1A1 and Hepatic fibrosis: It has also been described that the miR-200 family has multiple targets, each of which can affect different aspects of liver fibrosis, such as SIRT1, matrix metalloprotein-2 (MMP-2), Col1A1 production, protein kinase B in the PI3K/AKT pathway by targeting the transcriptional regulator friend of Gata 2 (FOG2), and mitogen-activated protein kinases (MAPK), which can exacerbate liver fibrosis [119,120,122].