PTEN and obesity due to melanocortin 4 receptor deficiency: A study demonstrated that the overexpression of miR-802 in mice liver by a phosphatase and tensin homolog (PTEN) and phosphatidylinositol-3 kinase (PI3K) can decrease protein kinase B (Akt) phosphorylation levels, contributing to the development of obesity by metabolism abnormalities [88].