KLF6 and Hepatic fibrosis: miR-101 is also downregulated in the fibrotic liver as well as in the activated HSCs and injured hepatocytes in the process of liver fibrosis, acting as suppressors of TGFβ signaling by targeting TGF-β receptor I (TβRI) and its transcriptional activator Kruppel-like factor 6 (KLF6) during liver fibrogenesis [144].