METTL1 and neoplasm: Our analysis demonstrated that there were significant differences in the expression of m7G-related genes BUD23 (p < 0.001), TRMT112 (p < 0.001), METTL1 (p < 0.001), WDR4 (p < 0.001), RAM (p < 0.001) and RNMT (p < 0.001) between the LUAD and normal samples, and all of them were highly expressed in tumor tissues (Supplementary Figure S1).