Findings reported that lesions to peripheral nerves increased the expression of CB2 in the dorsal root ganglia [21] and the spinal cord tissue [13,22] of rodents with neuropathy and CB2 agonists exerted anti-hyperalgesic effects [21,23,24,25,26] through the reduction of neuroinflammation and microgliosis. This evidence concerns the gene CNR2 and neuropathy.