TF RELA upregulates the target genes ICAM1, AP-1, IL6, and MMP9. Although we do not identify any virus gene binding to ICAM1, one study shows that ICAM1 facilitates RSV entry and infection of human epithelial cells by binding to its F protein which means that ICAM1 is significant for viral replication [37]. The gene discussed is JUN; the disease is infection.