Multiple truncating mutations in three negative regulators, including NF-κB inhibitor alpha (NFKBIA), cylindromatosis (CYLD), and TNF alpha-induced protein 3 (TNFAIP3), were found in NPC primary tumors in a whole-exome study at a high frequency [70,73]. The gene discussed is TNFAIP3; the disease is nasopharyngeal carcinoma.