A study comparing single nucleotide polymorphisms (SNPs) of 1583 NPC cases to 1894 controls of southern Chinese descent not only confirmed the association but also identified three additional susceptibility loci: TNFRSF19 on 13q12, MDS1-EVI1 on 3q26, and the CDKN2A-CDKN2B gene cluster on 9p21 [59]. The gene discussed is MECOM; the disease is nasopharyngeal carcinoma.