AKT1 and osteosarcoma: This study indicated that mPEG-b-P(C7-co-CA) micelles can inhibit the growth, migration, and invasion of osteosarcoma cells in vitro, and the transcriptional activity of the PI3K/Akt signaling pathway of osteosarcoma cells was also inhibited by mPEG-b-P(C7-co-CA) micelles treatments (Scheme 1).