We suggest that reduced TAM infiltration, caused by the complete loss of CCR4 (CCR4−/−) or CCR4 blockade (antagonist), was responsible for the decreased tumor mass, according to the improved survival and reduced macrophages observed in our experiments, along with the previously reported pro-tumorous attributes of tumor-associated macrophages [21,22,23,27,45,46]. The gene discussed is CCR4; the disease is neoplasm.