As depicted in Supplementary Figure S2A,B, it seems that the proportion and cell numbers of double-positive ITGB4 and PD-L1 cancer cells (ITGB4+PD-L1+) was high in the OSCC specimen, and the statistical result approached a significant difference (positivity p = 0.07, positive number p = 0.06). This evidence concerns the gene ITGB4 and cancer.