IFN-γ is a pro-inflammatory cytokine produced by T cells and NK cells that enhances the major histocompatibility complex (MHC) expression to promote neoantigen presentation in tumor cells by harnessing the IFN-γ/JAK/STAT1 pathway, thus expressing PD-L1 in cancer cells, inactivating T cells and attenuating immunosurveillance in the TME [45]. The gene discussed is CD274; the disease is neoplasm.