CD8A and neoplasm: However, the numbers of Tregs and exhausted CD8+ T cells around tumour cells within a 30 μm range were significantly higher in the PD-L1hi group than in the PD-L1lo group (4.55 × 10−2 vs. 2.33 × 10−4, p = 0.003; 1.04 × 10−2 vs. 0, p = 0.001, respectively) (Figure 4G,H).