In leukemic samples, we found significantly higher frequencies of degranulating CIK and NK cells (%CIKcell107a+/CIKcell: Kit M: 60 ± 19; Control: 43 ± 14; p = 0.05 and %NKcell107a+/NKcell: Kit M: 38 ± 16; Control: 21 ± 13; p = 0.02) (Figure 4A ‘AML’) and of CIKcellINFy+/CIKcell and NKcellINFy+/NKcell in MLCWB-DC(Kit M) compared to MLCWB-DC(Control) (%CIKcellINFy+/CIKcell: Kit M: 59 ± 17; Control: 20 ± 9; p = 0.0001 and %NKcellINFy+/NKcell: Kit M: 11 ± 9; Control: 3 ± 4; p = 0.026) (Figure 4B ‘AML’). Here, KIT is linked to acute myeloid leukemia.