SMARCA4 deficiency has been associated with elevated levels of tumor-infiltrating lymphocytes (TILs) [79,105], while ARID1A alterations were correlated with markedly high immune infiltrates in endometrial, stomach, and colon cancer but lower CD8+ T-cell infiltrations in ARID1A-mutant renal clear-cell carcinoma, indicating that the association between ARID1A alterations and immune infiltrates was cancer-dependent [31]. The gene discussed is ARID1A; the disease is malignant colon neoplasm.