For example, in a tumor cell without the expression of ARID1A, the elevated methyl transferase activity of EZH2 will suppress the function of Th1-type chemokines and IFN-g-responsive genes by converting H3K27 to H3K27me3 on the Th1-type chemokines and the IFN response promoters. The gene discussed is IFNG; the disease is neoplasm.