ARID1A and cancer: In addition, dysfunction of ARID1A impairs multiple pathways functioning for DNA damage repair, such as DSB repair, MMR, and the resolution of stress induced by the transcription–replication conflict, etc. To compensate for the compromised DNA damage repair, the cancer cells with ARID1A deficiency have to depend on other redundant DNA repair pathways, such as poly-ADP ribose polymerase (PARP), to survive.