Anti-Ro (anti-SS-A/Ro) antibodies directed against a small-molecule ribonucleoprotein containing RNA and proteins of 52 kDa and 60 kDa are found in many disease entities: SLE, cutaneous lupus, Sjögren’s syndrome (SS), scleroderma, and polymyositis. This evidence concerns the gene CALR and systemic lupus erythematosus.