The percentage of CD4+CXCR5+Foxp3−PD-1hi Tfh cells was reportedly higher in the peripheral blood of patients with active SLE than in the peripheral blood of healthy individuals, whereas the percentage of CD4+CXCR5+CD45RA−Foxp3hi-activated Tfr cells was lower [47]. Here, CD4 is linked to systemic lupus erythematosus.