HPRT1 expression was found to be upregulated in several cancer types, including BRCA, CESC, COAD, DLBC, ESCA, HNSC, LUAD, LUSC, PAAD, READ, SKCM, STAD, THYM, and UCEC, while it was downregulated in GBM, LAML, LGG, and TGCT (Figure S7A). The gene discussed is HPRT1; the disease is cancer.