HPRT1 and neoplasm: Furthermore, gene set enrichment analysis (GSEA) revealed that HPRT1 was positively associated with MYC targets, G2M checkpoint, tumor proliferation signature, DNA repair, cellular response to hypoxia, and ferroptosis, while it was negatively associated with ECM degradation, the P53 pathway, inflammatory response, and the IL10 anti-inflammatory signaling pathway (Figure 11B).