In rats without the induction of AP, pretreatment with warfarin caused a slight increase in the serum level of IL-1β, and this effect was statistically significant in rats pretreated with warfarin administered at doses of 180 and 270 μg/kg/dose (WF 180 + Saline and WF 270 + Saline). Here, IL1B is linked to alkaline phosphatase measurement.