In addition, as revealed by a luciferase reporter assay and rescue experimenthsa_circ_0070963 is confirmed to sponge miR-223-3p to inhibit HSC activation during liver fibrosis through regulating miR-223-3p and LEMD3 [58], while LEMD3 (called MAN1 as well), as the inner nuclear membrane protein, can inhibit the TGF-β receptor-mediated Smads pathway [58,80]. Here, LEMD3 is linked to Hepatic fibrosis.