From the mechanism perspective, CircCREBBP is the sponge for hsa-miR-1291, which up-regulates LEFTY2, thus alleviating liver fibrosis within TGF-β1-treated LX-2 cells, primary HSCs, and liver tissues from CCl4-induced HF mice, and liver fibrosis patients via the hsa-miR-1291/LEFTY2 axis [54]. Here, LEFTY2 is linked to hydrops fetalis.