There are some possible explanations for the lack of CRPs on EVs: lower CD59 content on the sEVs of bladder cancer patients due to higher CD59 levels on tumor cells or lower CD59 on EVs results in an overactive complement in the tumor microenvironment and this has deleterious effects due to chronic inflammation that promotes carcinogenesis [65]. Here, CD59 is linked to urinary bladder carcinoma.