TNF and Alzheimer disease: This is not a surprising finding; AD and AD-related dementia (ADRD) patients are at a higher risk of suicidal behaviors, as shown by Alipour-Haris et al. [207] in 12,538 US hospitalizations (2016–2018) related to suicidal behaviors and in suicidal ideators with late-life depression in whom TNF-α, APOE ε4 allele presence, CRP, and high-density lipoprotein cholesterol contributed most to suicidal ideation [208].