The overlap of P-tau, Aβ 42, α-synuclein, and TDP-43 is documented in the 202 autopsies and the brain MRI in young, seemingly healthy volunteers showing cortical and subcortical atrophy overlapping AD, PD, and FTLD patterns, including a striking caudate and cerebellar atrophy. The gene discussed is TARDBP; the disease is Cerebellar atrophy.