APOE and Alzheimer disease: Neuroinflammation plays an important role in AD and variants in APOE and the triggering receptor expressed on myeloid cells 2 (TREM2)—a microglial receptor–adaptor complex, expressed on myeloid cells 2 and which three domains are key for the binding of pathogen-associated pattern molecules PAMPS (the release of protective molecules for microglial survival and the propagation of proinflammatory signals) are linked to APOE [91,92,93].