We have described the remarkable AD, PD, and TDP-43 pathology overlap in young MMC residents and the fact that it is very similar to the mixed protein pathologies in elderly patients with AD, frontotemporal lobar dementia (FTLD), Lewy body disease (LBD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), cerebral amyloid angiopathy (CAA), and in younger than 60 y AD patients [180,184,192,193,194,195,196]. The gene discussed is TARDBP; the disease is Alzheimer disease.