To confirm the potent anti-inflammatory actions described for MaR1 on adipose tissue in obesity, we proved the ability of this SPM to regulate the adipokines’ expression in different animal tissues of DIO mice and to counteract the alterations induced by TNF-α in two models of cultured human adipocytes (hSP and hMSC) from overweight/obese subjects. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.