Indeed, ATP13A2 has been implicated in several human cancers, including melanoma [37], colon cancer [38], hepatocellular carcinoma [39], acute myeloid leukemia [40] and non-small-cell lung cancer [41], while ATP13A3 has been linked to pancreatic cancer and colorectal cancer [42,43,44]. This evidence concerns the gene ATP13A3 and colonic neoplasm.