With respect to this, HNF1β connects NAFLD with diabetes, which is underlined by the finding that mutated HNF1β alleles are associated with diabetes type MODY5 (maturity-onset diabetes of the young) [404] as well as type-II diabetes [405], suggesting that HNF1β activity mitigates insulin resistance, at least in these pathologies. Here, HNF1B is linked to diabetes mellitus.