For example, the most conserved surface on Transport and Golgi organisation protein 2 homolog (TANGO2) has four clinically significant mutations linked to metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration (MECRCN), and it is not characterised as a known interface or active site (Figure 3I). This evidence concerns the gene TANGO2 and cardiac arrhythmia.