In patients with glioma, highly expressed GSDMD was negatively correlated with B cell (p < 0.0001, Figure 6C) and CD4+ T cell (p < 0.0001, Figure 6D) infiltrations and positively correlated with cancer-associated fibroblasts (CAFs) (p < 0.0001, Figure 6E) and macrophages (p < 0.0001, Figure 6F). Here, CD4 is linked to central nervous system cancer.