For instance, hyperlipidemic mice deficient for gasdermin D were protected against aortic rupture resulting from Ang II infusion (hyperlipidemia induced by inoculating adeno-associated virus encoding a human proprotein convertase subtilisin/kexin type 9 gain-of-function of mutation (D377Y) or long-term feeding lysyl oxidase inhibitor β-aminopropionitrile [50]). This evidence concerns the gene LOX and hyperlipidemia.