NPM1 and acute myeloid leukemia: For example, EVs’ FLT3-ITD and NPM1 mRNAs serve for determining AML prognosis; FLT3-ITD, IGF-IR, and CXCR4 mRNAs help in AML treatment, whereas IGF-IR, CXCR4, and MMP4 mRNAs aid in understanding the behavior of the tumor niche [197].