Aspirin-exacerbated respiratory disease (AERD) is an inflammatory condition that consists of three clinical features: asthma, rhinosinusitis with recurrent NPs, and sensitivity to non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, that inhibit cyclooxygenase-1 (COX-1), a synthetic enzyme of PGs [108]. Here, PTGS1 is linked to asthma.