VEGFA and gastrointestinal stromal tumor: It was recently observed that epigenetic regulation might also play a major role in GIST vascularization control, as the upregulation of the histone demethylase KDM4D was demonstrated to affect promoters of the H3K9me3 and H3K36me3 genes, enhancing the angiogenesis in vivo through the HIF1β/VEGFA pathway stimulation, leading to the overexpression of CD31 [74].