MMP9 and gastrointestinal stromal tumor: For example, it was reported that BRD4 upregulation enhanced GIST migration and invasion by regulating angiogenesis through the NF-kB/CCL2 signaling pathway, while CCL2 is also useful to recruit tumor-associated macrophages, increasing the cancer microvessel density and secreting several pro-angiogenic molecules such as VEGFA, LOX and MMP9 [32,71].