In particular, HIF proteins also enhance the stem features of cancer cells and contribute to their differentiation through the EET, by losing cell polarity, increasing the invasive ability and upregulating Twist and Snail, causing the consequent downregulation of the tight junction proteins, E-cadherin and Occludin, together with the upregulation of angiogenesis-related molecules such as VE-cadherin, vitronectin and fibronectin [8]. Here, CDH5 is linked to cancer.