The co-treatment of GC cells with MK-2206, an Akt inhibitor, and EF24 induces ROS generation via the stimulation of the endoplasmic reticulum through the activation of CHOP and ATF-4, thus decreasing the mitochondrial membrane potential and inducing apoptosis via the Bcl-2/Bax protein ratio dysregulation [49]. Here, BCL2 is linked to gastric cancer.