MCR participants had the highest TNF-α level (9.5 ± 2.6 pg./mL) compared with slow gait (8.5 ± 2.8 pg./mL), subjective cognitive decline (7.1 ± 1.4 pg./mL) and healthy (7.0 ± 1.7 pg./mL) groups and, conversely, the lowest progranulin/TNF-α and IL-10/TNF-α ratio. This evidence concerns the gene TNF and Mental deterioration.