Consistent with the data shown at 6 h post-stroke, there was significantly upregulated expression of NLRP3, ASC, cleaved-caspase-1, and its downstream target GSDMD-N in the penumbra at 24 h after stroke (Figure 4A,B, ** p < 0.01, *** p < 0.001 vs. Sham group), while it could be partially reversed by the induction of IPC (#p < 0.05, ##p < 0.01 vs. pMCAO group). Here, CASP1 is linked to stroke disorder.